Corin is highly expressed in atherosclerosis models
Autor: | Jingjing Jiang, Quan Zhou, Mingcheng Sun, Fuwen Zuo |
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Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine Cardiac function curve medicine.medical_specialty medicine.drug_class Biophysics Stimulation 030204 cardiovascular system & hematology Biochemistry Antibodies Mice 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine medicine.artery Internal medicine Human Umbilical Vein Endothelial Cells Natriuretic peptide medicine Animals Humans Autocrine signalling Molecular Biology Aorta Serine protease biology business.industry Gene Expression Profiling Serine Endopeptidases Cell Biology Atherosclerosis Pathophysiology Lipoproteins LDL Mice Inbred C57BL Disease Models Animal 030104 developmental biology Endocrinology Gene Expression Regulation Microscopy Fluorescence cardiovascular system biology.protein business |
Zdroj: | Biochemical and Biophysical Research Communications. 504:440-446 |
ISSN: | 0006-291X |
DOI: | 10.1016/j.bbrc.2018.08.173 |
Popis: | Corin is a serine protease mainly expressed in the heart, where it regulates blood pressure and cardiac function through activating pro-atrial natriuretic peptide (pro-ANP) to ANP. Its expression has also been detected in non-cardiac tissues. However, there is no report so far about the distribution and function of corin in aorta and in related diseases such as atherosclerosis. This study was the first to explore corin expression in aorta both under normal conditions and in atherosclerosis models. In vivo, we found corin had a basal level of expression in aortas, mainly in intimal endothelial cells and was significantly elevated in mouse atherosclerosis model. Moreover, we observed pro-ANP, the specific substrate of corin, was also expressed in mice aortas and increased in mouse atherosclerosis model. In vitro, we further demonstrated corin expression in cultured vascular endothelial cells and its induced expression after ox-LDL stimulation. Our results suggested that corin may play important roles in aorta physiology and in the pathophysiological process of atherosclerosis in an autocrine manner and has potential clinical value for the treatment of atherosclerosis. |
Databáze: | OpenAIRE |
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