Embryo Biopsy for PGD: Current Perspective

Autor:	J Marshall, M. Traversa, Robert P.S. Jansen, Steven J. McArthur, Don Leigh
Rok vydání:	2012
Předmět:	Gynecology medicine.medical_specialty Polar body Pathology Somatic mosaicism medicine.diagnostic_test Biopsy medicine Tissue sample Fish Embryo Embryo biopsy Biology
Zdroj:	Practical Manual of In Vitro Fertilization ISBN: 9781441917799 Clinical Embryology ISBN: 9781461483755 Gamete Assessment, Selection and Micromanipulation in ART ISBN: 9781461483595
Popis:	To date, it is blastocyst-stage biopsy that has given valuable improvement in implantation rates, and it waits to be seen whether the still prevalent day 3 biopsies and day 0–1 biopsies of polar bodies can achieve the same outcomes. With the use of a DNA amplification-based approach, the interpretation problems associated with low-level somatic mosaicism common in embryos and seen with FISH are partially overcome. The tissue sample, typically consisting of 3–5 cells, is analyzed as a whole (and is taken to represent the embryo as a whole), thus producing an averaging effect for the constitutional chromosomes under investigation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d001ef2d585b1670ea6520b5e7d86d https://doi.org/10.1007/978-1-4419-1780-5_52 Zobrazit plný text záznamu