Prognostic role of diffusion weighted and dynamic contrast-enhanced MRI in loco-regionally advanced head and neck cancer treated with concomitant chemoradiotherapy
| Autor: | Primoz Strojan, Katarina Surlan-Popovic, Manca Garbajs |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
diffusion-weighted imaging overall survival concomitant chemoradiotherapy R895-920 Contrast Media Kaplan-Meier Estimate Statistics Nonparametric 030218 nuclear medicine & medical imaging 03 medical and health sciences Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging skin and connective tissue diseases Aged Univariate analysis Hypopharyngeal Neoplasms Receiver operating characteristic business.industry Proportional hazards model Head and neck cancer Radiotherapy Dosage Chemoradiotherapy Middle Aged Prognosis medicine.disease Magnetic Resonance Imaging Squamous carcinoma Oropharyngeal Neoplasms stomatognathic diseases squamous cell head and neck cancer Diffusion Tensor Imaging ROC Curve Oncology 030220 oncology & carcinogenesis Dynamic contrast-enhanced MRI Regression Analysis Female Radiotherapy Intensity-Modulated Nuclear medicine business dynamic contrast-enhanced mri Research Article Diffusion MRI |
| Zdroj: | Radiology and Oncology, Vol 53, Iss 1, Pp 39-48 (2019) Radiology and Oncology |
| ISSN: | 1581-3207 |
| Popis: | Background In the study, the value of pre-treatment dynamic contrast-enhanced (DCE) and diffusion weighted (DW) MRI-derived parameters as well as their changes early during treatment was evaluated for predicting disease-free survival (DFS) and overall survival (OS) in patients with locoregionally advanced head and neck squamous carcinoma (HNSCC) treated with concomitant chemoradiotherapy (cCRT) with cisplatin. Patients and methods MRI scans were performed in 20 patients with locoregionally advanced HNSCC at baseline and after 10 Grays (Gy) of cCRT. Tumour apparent diffusion coefficient (ADC) and DCE parameters (volume transfer constant [Ktrans], extracellular extravascular volume fraction [ve], and plasma volume fraction [Vp]) were measured. Relative changes in parameters from baseline to 10 Gy were calculated. Univariate and multivariate Cox regression analysis were conducted. Receiver operating characteristic (ROC) curve analysis was employed to identify parameters with the best diagnostic performance. Results None of the parameters was identified to predict for DFS. On univariate analysis of OS, lower pre-treatment ADC (p = 0.012), higher pre-treatment Ktrans (p = 0.026), and higher reduction in Ktrans (p = 0.014) from baseline to 10 Gy were identified as significant predictors. Multivariate analysis identified only higher pre-treatment Ktrans (p = 0.026; 95% CI: 0.000–0.132) as an independent predictor of OS. At ROC curve analysis, pre-treatment Ktrans yielded an excellent diagnostic accuracy (area under curve [AUC] = 0.95, sensitivity 93.3%; specificity 80 %). Conclusions In our group of HNSCC patients treated with cisplatin-based cCRT, pre-treatment Ktrans was found to be a good predictor of OS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|