PACAP modulates the consolidation and extinction of the contextual fear conditioning through NMDA receptors
| Autor: | Cristiane Regina Guerino Furini, Bianca E. Schmidt, Scheila Daiane Schmidt, Jociane de Carvalho Myskiw, Ivan Izquierdo, Lorena Evelyn Silva Cavalcante |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
endocrine system Cognitive Neuroscience Conditioning Classical Hippocampus Experimental and Cognitive Psychology Motor Activity Neuroprotection Receptors N-Methyl-D-Aspartate Extinction Psychological Behavioral Neuroscience chemistry.chemical_compound medicine Animals Rats Wistar Neurotransmitter CA1 Region Hippocampal biology Basolateral Nuclear Complex Glutamate receptor Extinction (psychology) Fear Rats medicine.anatomical_structure nervous system chemistry biology.protein NMDA receptor Pituitary Adenylate Cyclase-Activating Polypeptide Psychology Neuroscience hormones hormone substitutes and hormone antagonists Basolateral amygdala Neurotrophin |
| Zdroj: | Neurobiology of learning and memory. 118 |
| ISSN: | 1095-9564 |
| Popis: | Pituitary adenylate cyclase-activating polypeptide (PACAP) has a broad spectrum of biological functions including neurotransmitter, neurotrophic and neuroprotective. Moreover, it has been suggested that PACAP plays a role in the modulation of learning and memory as well as on the modulation of glutamate signaling. Thus, in the current study we investigated in the CA1 region of hippocampus and in the basolateral amygdala (BLA) the role of PACAP in the consolidation and extinction of contextual fear conditioning (CFC) and the interaction between PACAP and NMDA receptors. Male rats with cannulae implanted in the CA1 region of the hippocampus or in the BLA received immediately after the training or extinction training of the CFC infusions of the Vehicle, PACAP-38 (40 pg/side), PACAP 6-38 (40 pg/side) or PACAP 6-38 plus D-serine (50 μg/side). After 24 h, the animals were subjected to a 3-min retention test. The results indicated that in the CA1 region of hippocampus, PACAP participates in the consolidation and extinction of the CFC, and in the BLA, PACAP participates only in the consolidation of the CFC. Additionally, the results suggest that the action of PACAP on the consolidation and extinction of the CFC is mediated by the glutamate NMDA receptors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect