Two sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C
| Autor: | Luydson Richardson Silva Vasconcelos, Leila Maria Moreira Beltrão Pereira, Dayse Celia Barbosa Lins Aroucha, Raul Emídio de Lima, Rodrigo Feliciano do Carmo, Cyntia Maria de Holanda Martins, Patrícia Moura |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Carcinoma Hepatocellular Genotype Hepatitis C virus Immunology Complement Membrane Attack Complex Hepacivirus medicine.disease_cause Gastroenterology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Fibrosis Internal medicine medicine Immunology and Allergy Humans Genetic Predisposition to Disease Alleles Aged business.industry Complement component 7 Liver Neoplasms General Medicine Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Complement C7 Genotype frequency 030104 developmental biology Liver 030220 oncology & carcinogenesis Hepatocellular carcinoma Female business Hepatic fibrosis |
| Zdroj: | Human immunology. 79(9) |
| ISSN: | 1879-1166 |
| Popis: | The complement system (CS) is a key element of immunity against pathogens but also seems to influence other events, such as tumorigenesis and tissue repair. Complement component 7 (C7) is a key component of the lytic pathway of CS, leading to the formation of the membrane attack complex (MAC). This study aimed to investigate the existence of the association of a polymorphism in the C7 gene, rs1063499, with hepatic fibrosis and the occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis C. We analyzed 456 samples from patients with chronic hepatitis C. Real-time PCR was used for allelic discrimination. Patients were classified by their METAVIR score as F1 (n = 100), F2 (n = 83), F3 (n = 101) or F4 (n = 66); 106 patients were diagnosed with HCC. Patients carrying the G/G genotype of C7 had a lower chance of developing severe fibrosis in the recessive model (p = 0.042; OR: 0.65 95% CI 0.41–1.02). However, the G/G genotype frequency was higher in patients with HCC (P = 0.01; OR: 2.07 95% CI 1.20–3.53) and in those with larger tumors (p = 0.04). The G/G C7 genotype seems to be a protective factor against advanced fibrosis; however, it was associated with a higher risk of HCC and the occurrence of larger hepatic nodules, suggesting the involvement of C7 in the physiopathogenesis of HCC and fibrosis in patients with hepatitis C virus (HCV). |
| Databáze: | OpenAIRE |
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