Terbinafine in the Treatment of Trichophyton Tinea Capitis: A Randomized, Double-Blind, Parallel-Group, Duration-Finding Study
| Autor: | Anne W. Lucky, LindaAnn Wraith, Aditya K. Gupta, Bernice R. Krafchik, Raza Aly, Daniel Stewart, Carle Paul, Jeffrey L. Blumer, Bea B. Abrams, Dennis E. Babel, Sheila Fallon Friedlander, Nouciba Gourmala, Paul J. Honig |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Antifungal Agents Gastrointestinal Diseases Population Administration Oral Naphthalenes Drug Administration Schedule law.invention Double-Blind Method Randomized controlled trial law medicine Humans Trichophyton Child education Adverse effect Terbinafine Tinea Capitis Trichophyton tonsurans education.field_of_study biology business.industry Headache biology.organism_classification medicine.disease Dermatology Regimen Child Preschool Pediatrics Perinatology and Child Health Female Tinea capitis business medicine.drug |
| Zdroj: | Pediatrics. 109:602-607 |
| ISSN: | 1098-4275 0031-4005 |
| Popis: | Objectives. Terbinafine has been shown to be effective in tinea capitis, using different treatment durations. However, no direct comparison of treatment duration has previously been investigated. This randomized, double-blind, parallel-group, multicenter study was designed to assess the effect of terbinafine treatment duration on the outcome of Trichophyton tinea capitis in a North American population. Methods. A total of 176 patients with a clinical diagnosis of tinea capitis were enrolled in this study and treated with oral terbinafine (3–6 mg/kg/d) for 1, 2, or 4 weeks. All patients were to be followed until week 12. A total of 159 patients had culture-confirmed tinea capitis attributable to Trichophyton species and constituted the intent-to-treat population used for efficacy analysis (50, 55, and 54 patients in the 1-, 2-, and 4-week arms, respectively). Results. At the end of study, effective treatment, defined as negative culture and low scores on signs and symptoms, was achieved in 56%, 69%, and 65% of patients who were treated with terbinafine for 1, 2, and 4 weeks, respectively. A negative culture was achieved in 60%, 76%, and 72%, respectively. Overall, the efficacy data showed that both the 2- and 4-week treatment regimens are clinically superior to the 1-week regimen. Terbinafine was well tolerated, and the incidence of adverse events showed no relationship to the duration of therapy. Conclusion. When efficacy, cost, and compliance are taken into consideration, 2 weeks of terbinafine therapy appears to be the optimal treatment duration for patients with Trichophyton tonsurans tinea capitis. |
| Databáze: | OpenAIRE |
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