Reorganization of early visual cortex functional connectivity following selective peripheral and central visual loss
| Autor: | José-Alain Sahel, Avinoam B. Safran, Norman Sabbah, Saddek Mohand-Said, Amir Amedi, Colas N. Authié, Christophe Habas, Nicolae Sanda |
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| Přispěvatelé: | Institut de la Vision, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO), Hôpital Foch [Suresnes], University College of London [London] (UCL), Fondation Ophtalmologique Adolphe de Rotschild, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), The Hebrew University of Jerusalem (HUJ), Geneva University Hospital (HUG), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male genetic structures Adolescent Biology Brain mapping 050105 experimental psychology Article Visual processing 03 medical and health sciences Macular Degeneration Young Adult 0302 clinical medicine Retinitis pigmentosa Neuroplasticity Neural Pathways medicine Humans Stargardt Disease 0501 psychology and cognitive sciences Computer vision Visual Cortex Brain Mapping Multidisciplinary Neuronal Plasticity business.industry 05 social sciences Brain Macular degeneration Middle Aged medicine.disease Magnetic Resonance Imaging eye diseases Visual field Visual cortex medicine.anatomical_structure Peripheral vision [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Artificial intelligence Visual Fields business Neuroscience 030217 neurology & neurosurgery [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Retinitis Pigmentosa |
| Zdroj: | Scientific Reports Scientific Reports, 2017, 7, pp.43223. ⟨10.1038/srep43223⟩ Scientific Reports, Nature Publishing Group, 2017, 7, pp.43223. ⟨10.1038/srep43223⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep43223⟩ |
| Popis: | Behavioral alterations emerging after central or peripheral vision loss suggest that cerebral reorganization occurs for both the afferented and deafferented early visual cortex (EVC). We explored the functional reorganization of the central and peripheral EVC following visual field defects specifically affecting central or peripheral vision. Compared to normally sighted, afferented central and peripheral EVC enhance their functional connectivity with areas involved in visual processing, whereas deafferented central and peripheral EVC increase their functional connectivity with more remote regions. The connectivity pattern of afferented EVC suggests adaptive changes that might enhance the visual processing capacity whereas the connectivity pattern of deafferented EVC may reflect the involvement of these regions in high-order mechanisms. Characterizing and understanding the plastic changes induced by these visual defects is essential for any attempt to develop efficient rehabilitation strategies. |
| Databáze: | OpenAIRE |
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