Serum Exosomal miRNA-1915-3p Is Correlated With Disease Activity of Korean Rheumatoid Arthritis
| Autor: | Jihyung Yoo, Soon Ae Kim, Mi-Kyoung Lim, Chunhwa Ihm, Dong-Hyuk Sheen, Sang Kwang Lee |
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| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Treatment response Exosomes General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Disease activity 03 medical and health sciences 0302 clinical medicine Republic of Korea microRNA medicine Humans In patient Pharmacology business.industry medicine.disease Microvesicles Pathophysiology MicroRNAs 030220 oncology & carcinogenesis Rheumatoid arthritis Immunology Biomarker (medicine) business Biomarkers Research Article |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 0258-851X |
| DOI: | 10.21873/invivo.12124 |
| Popis: | Background/aim It has been found that microRNAs (miRNA) affect rheumatoid arthritis (RA) pathophysiology. This study aimed to identify novel serum exosomal miRNAs related to RA disease activity in patients with an inadequate treatment response. Patients and methods The sample population comprised clinical remission (CR) and non-clinical remission (non-CR) groups of RA patients. To identify potent miRNA markers for RA disease activity, miRNA array and qPCR were performed after patient serum exosomes preparation. Results Has-miR-1915-3p and has-miR-6511b-5p were significantly higher in the serum exosomes of the CR group. The level of serum C-reactive protein (CRP) was negatively correlated with has-miR-1915-3p level in serum exosomes. Conclusion Has-miR-1915-3p may be a potential marker for Korean RA disease activity. |
| Databáze: | OpenAIRE |
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