A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
| Autor: | Larry A. Sklar, Eric R. Prossnitz, Chetana M. Revankar, Daniel F. Cimino, Jeffrey B. Arterburn |
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| Rok vydání: | 2005 |
| Předmět: |
Membrane estrogen receptor
Cell signaling Nuclear Envelope medicine.drug_class Recombinant Fusion Proteins Estrogen receptor Biology Endoplasmic Reticulum Transfection Cell Line Receptors G-Protein-Coupled Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Cell Line Tumor medicine Animals Humans Estrogen receptor beta PELP-1 Cell Nucleus Multidisciplinary Estradiol Cell Membrane Estrogen Receptor alpha Estrogens Cell biology ErbB Receptors Protein Transport Antisense Elements (Genetics) Receptors Estrogen Biochemistry Estrogen G-Protein Coupled Estrogen Receptor 1 Calcium Estrogen receptor alpha hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | Science. 307:1625-1630 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | The steroid hormone estrogen regulates many functionally unrelated processes in numerous tissues. Although it is traditionally thought to control transcriptional activation through the classical nuclear estrogen receptors, it also initiates many rapid nongenomic signaling events. We found that of all G protein–coupled receptors characterized to date, GPR30 is uniquely localized to the endoplasmic reticulum, where it specifically binds estrogen and fluorescent estrogen derivatives. Activating GPR30 by estrogen resulted in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology. |
| Databáze: | OpenAIRE |
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