Multi-gene signature of microcalcification and risk prediction among Taiwanese breast cancer
| Autor: | Chi Jung Huang, Yuan Soon Ho, Hsin Tien Tsai, Shih Hsin Tu, Ching Shui Huang, Ling Ming Tseng, Chih Yi Liu, Chao Chiang Tu, Chi Cheng Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Taiwan lcsh:Medicine Breast Neoplasms Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Exome Sequencing medicine Genetics Biomarkers Tumor Humans skin and connective tissue diseases lcsh:Science Pathological Gene Exome sequencing Early Detection of Cancer Cancer Oligonucleotide Array Sequence Analysis Regulation of gene expression Multidisciplinary Comedo business.industry Gene Expression Profiling lcsh:R Calcinosis Bayes Theorem medicine.disease Prognosis Protein ubiquitination Computational biology and bioinformatics Gene Expression Regulation Neoplastic 030220 oncology & carcinogenesis Female lcsh:Q Microcalcification medicine.symptom business |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Microcalcification is one of the most common radiological and pathological features of breast ductal carcinoma in situ (DCIS), and to a lesser extent, invasive ductal carcinoma. We evaluated messenger RNA (mRNA) transcriptional profiles associated with ectopic mammary mineralization. A total of 109 breast cancers were assayed with oligonucleotide microarrays. The associations of mRNA abundance with microcalcifications and relevant clinical features were evaluated. Microcalcifications were present in 86 (79%) patients by pathological examination, and 81 (94%) were with coexistent DCIS, while only 13 (57%) of 23 patients without microcalcification, the invasive diseases were accompanied with DCIS (χ2-test, P P = 0.10). Our study suggested that microcalcification is not only the earliest detectable radiological sign for mammography screening but the phenomenon itself may reflect the underling events during mammary carcinogenesis. Future studies to evaluate the prognostic significance of microcalcifications are warranted. |
| Databáze: | OpenAIRE |
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