Mechanisms governing the visco-elastic responses of living cells assessed by foam and tensegrity models

Autor: Daniel Isabey, Sylvie Wendling-Mansuy, Patrick Cañadas, Patrick Chabrand, Valérie Laurent
Přispěvatelé: Physiopathologie et Thérapeutiques Respiratoires, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10, Laboratoire d'Aérodynamique et de Biomécanique du Mouvement (LABM), Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2, Laboratoire de Biomécanique et Biomatériaux Ostéo-Articulaires (LBBOA), Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Rosu, Elena
Jazyk: angličtina
Rok vydání: 2003
Předmět:
0206 medical engineering
Biomedical Engineering
Modulus
02 engineering and technology
Models
Biological
Viscoelasticity
Cell Physiological Phenomena
03 medical and health sciences
Viscosity
Multimodular cytoskeleton
[SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
Tensegrity
Animals
Elasticity (economics)
[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph]
Cytoskeleton
Open unit-cell model
030304 developmental biology
Physics
0303 health sciences
business.industry
Cell micromanipulation
[PHYS.MECA.BIOM] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph]
Time constant
[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
Structural engineering
Mechanics
Actin cytoskeleton
020601 biomedical engineering
Elasticity
Computer Science Applications
Actin Cytoskeleton
Structural viscosity
Viscosity modulus
Actin filaments
business
Zdroj: Medical and Biological Engineering and Computing
Medical and Biological Engineering and Computing, Springer Verlag, 2003, 41, pp.733-739. ⟨10.1007/BF02349982⟩
Medical and Biological Engineering and Computing, 2003, 41, pp.733-739. ⟨10.1007/BF02349982⟩
ISSN: 0140-0118
1741-0444
DOI: 10.1007/BF02349982⟩
Popis: The visco-elastic properties of living cells, measured to date by various authors, vary considerably, depending on the experimental methods and/or on the theoretical models used. In the present study, two mechanisms thought to be involved in cellular visco-elastic responses were analysed, based on the idea that the cytoskeleton plays a fundamental role in cellular mechanical responses. For this purpose, the predictions of an open unit-cell model and a 30-element visco-elastic tensegrity model were tested, taking into consideration similar properties of the constitutive F-actin. The quantitative predictions of the time constant and viscosity modulus obtained by both models were compared with previously published experimental data obtained from living cells. The small viscosity modulus values (10(0)-10(3) Pa x s) predicted by the tensegrity model may reflect the combined contributions of the spatially rearranged constitutive filaments and the internal tension to the overall cytoskeleton response to external loading. In contrast, the high viscosity modulus values (10(3)-10(5) Pa x s) predicted by the unit-cell model may rather reflect the mechanical response of the cytoskeleton to the bending of the constitutive filaments and/or to the deformation of internal components. The present results suggest the existence of a close link between the overall visco-elastic response of micromanipulated cells and the underlying architecture.
Databáze: OpenAIRE
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