Evaluation of Analgesic and Anti-inflammatory Potential of 80% Methanol Leaf Extract of Otostegia integrifolia Benth (Lamiaceae)
| Autor: | Hiwot Ayalew, Besufekad Abebe, Abel Degu, Rediet Tesfaye |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aspirin food.ingredient Traditional medicine medicine.drug_class Immunology Analgesic Anti-inflammatory Carrageenan 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine food chemistry In vivo 030220 oncology & carcinogenesis medicine Otostegia integrifolia Morphine Immunology and Allergy Otostegia Journal of Inflammation Research medicine.drug |
| Zdroj: | Journal of Inflammation Research. 13:1175-1183 |
| ISSN: | 1178-7031 |
| DOI: | 10.2147/jir.s285932 |
| Popis: | Rediet Tesfaye,1 Abel Degu,1 Besufekad Abebe,2 Hiwot Ayalew2 1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Abel DeguDepartment of Pharmacology and Clinical Pharmacy School of Pharmacy, College of Health Sciences, Addis Ababa University, PO Box 1176, Addis Ababa, EthiopiaEmail abel.degu@aau.edu.etIntroduction: Pain and inflammatory disorders are the most prevalent syndromes. Different herbs were used for treatment of pain and inflammation including members of the genus Otostegia. As a result, this research investigated the in vivo analgesic and anti-inflammatory effects of 80% methanol leaf extract of Otostegia integrifolia in mice.Methods: The analgesic and anti-inflammatory effects of the plant was evaluated using hot plate method, acetic-acid induced writhing test, and carrageenan and formalin induced paw edema. Three experimental groups (100, 200, and 400 mg/kg) received the extract while morphine 10 mg/kg and aspirin 150 mg/kg were used as a positive control for analgesic and anti-inflammatory tests accordingly. Distilled water (10 mL/kg) was used as negative control.Results: From the experimental groups, OI400 displayed significant analgesic and anti-inflammatory activities (P< 0.001). In acetic acid induced writhing tests, the number of writhes decreased significantly (P< 0.001) in all experimental groups. Similarly, OI400 reduced the mean paw edema significantly in carrageenan and formalin induced paw edema (P< 0.05 and P< 0.001, respectively).Conclusion: In general, the results obtained in this study demonstrated that the extract exhibited significant analgesic and anti-inflammatory potential in mice.Keywords: analgesic activity, anti-inflammatory, hot plate, Otostegia integrifolia, carrageenan |
| Databáze: | OpenAIRE |
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