In vitro assessment of arsenic mobility in historical mine waste dust using simulated lung fluid
| Autor: | Dora C Pearce, Stafford McKnight, Singarayer Florentine, Scott Nankervis, Kim Dowling, Rachael Martin |
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| Rok vydání: | 2016 |
| Předmět: |
Environmental Engineering
Victoria Pulmonary toxicity 0211 other engineering and technologies chemistry.chemical_element Biological Availability Industrial Waste 02 engineering and technology 010501 environmental sciences In Vitro Techniques 01 natural sciences Models Biological Mining Arsenic X-Ray Diffraction Geochemistry and Petrology Scorodite medicine Environmental Chemistry Ingestion Humans Solubility Particle Size Dissolution Lung 0105 earth and related environmental sciences General Environmental Science Water Science and Technology 021110 strategic defence & security studies Waste management Inhalation Chemistry Reproducibility of Results Dust General Medicine Body Fluids medicine.anatomical_structure Environmental chemistry Gold |
| Zdroj: | Environmental geochemistry and health. 40(3) |
| ISSN: | 1573-2983 |
| Popis: | Exposure studies have linked arsenic (As) ingestion with disease in mining-affected populations; however, inhalation of mine waste dust as a pathway for pulmonary toxicity and systemic absorption has received limited attention. A biologically relevant extractant was used to assess the 24-h lung bioaccessibility of As in dust isolated from four distinct types of historical gold mine wastes common to regional Victoria, Australia. Mine waste particles less than 20 µm in size (PM20) were incubated in a simulated lung fluid containing a major surface-active component found in mammalian lungs, dipalmitoylphosphatidylcholine. The supernatants were extracted, and their As contents measured after 1, 2, 4, 8 and 24 h. The resultant As solubility profiles show rapid dissolution followed by a more modest increasing trend, with between 75 and 82% of the total 24-h bioaccessible As released within the first 8 h. These profiles are consistent with the solubility profile of scorodite, a secondary As-bearing phase detected by X-ray diffraction in one of the investigated waste materials. Compared with similar studies, the cumulative As concentrations released at the 24-h time point were extremely low (range 297 ± 6–3983 ± 396 µg L−1), representing between 0.020 ± 0.002 and 0.036 ± 0.003% of the total As in the PM20. |
| Databáze: | OpenAIRE |
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