Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report
| Autor: | Guo Ye, Yang Wenyu, Han Zhongchao, Liu Fang, Wang Weiqiang, Ruan Min, Han Zhibo, Chang Lixian, Chen Xiaojuan, Zhu Xiaofan, Lim Meikuang |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty aplastic anemia Lymphocyte Biomedical Engineering lcsh:Medicine Mesenchymal Stem Cell Transplantation Gastroenterology Umbilical cord 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans hepatitis Aplastic anemia Hepatitis Transplantation Case Study business.industry lcsh:R Mesenchymal stem cell Anemia Aplastic Infant Mesenchymal Stem Cells Cell Biology medicine.disease Severe Aplastic Anemia Pediatric patient Haematopoiesis 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis mesenchymal stromal cell umbilical cord business |
| Zdroj: | Cell Transplantation Cell Transplantation, Vol 30 (2021) |
| ISSN: | 1555-3892 0963-6897 |
| DOI: | 10.1177/0963689720977144 |
| Popis: | Here we presented a case of a 19-month-old boy who developed severe aplastic anemia postacute hepatitis. He was treated successfully with the umbilical cord-derived mesenchymal stromal cells (UC-MSCs) infusion and cyclosporine A (CsA). The boy achieved both hematopoietic recovery and normal lymphocyte proportion. So far, his condition still remains stable. To our knowledge, there is a rare previous report on the utility of MSCs infusion for the treatment of hepatitis-associated aplastic anemia (HAAA). Considering the efficacy, safety, and strong operability, particularly for pediatric patient, the infusion of UC-MSCs combined with CsA could be an effective alternative for the treatment of HAAA. |
| Databáze: | OpenAIRE |
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