A Novel Shadowgraphic Inline Measurement Technique for Image-Based Crystal Size Distribution Analysis
| Autor: | D. Wirz, Andreas Seidel-Morgenstern, Erik Temmel, Marc Hofmann, Hans-Jörg Bart, Heike Lorenz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microscope
Materials science General Chemical Engineering Analytical chemistry 02 engineering and technology crystal size measurement law.invention Inorganic Chemistry Crystal 020401 chemical engineering law Microscopy lcsh:QD901-999 General Materials Science 0204 chemical engineering Crystallization Suspension (vehicle) inline probe Supersaturation Aqueous solution 021001 nanoscience & nanotechnology Condensed Matter Physics Particle crystal needles lcsh:Crystallography ddc:620 0210 nano-technology optical measurement techniques |
| Zdroj: | Crystals, Vol 10, Iss 740, p 740 (2020) Crystals Volume 10 Issue 9 |
| ISSN: | 2073-4352 |
| Popis: | A novel shadowgraphic inline probe to measure crystal size distributions (CSD), based on acquired greyscale images, is evaluated in terms of elevated temperatures and fragile crystals, and compared to well-established, alternative online and offline measurement techniques, i.e., sieving analysis and online microscopy. Additionally, the operation limits, with respect to temperature, supersaturation, suspension, and optical density, are investigated. Two different substance systems, potassium dihydrogen phosphate (prisms) and thiamine hydrochloride (needles), are crystallized for this purpose at 25 L scale. Crystal phases of the well-known KH2PO4/H2O system are measured continuously by the inline probe and in a bypass by the online microscope during cooling crystallizations. Both measurement techniques show similar results with respect to the crystal size distribution, except for higher temperatures, where the bypass variant tends to fail due to blockage. Thiamine hydrochloride, a substance forming long and fragile needles in aqueous solutions, is solidified with an anti-solvent crystallization with ethanol. The novel inline probe could identify a new field of application for image-based crystal size distribution measurements, with respect to difficult particle shapes (needles) and elevated temperatures, which cannot be evaluated with common techniques. |
| Databáze: | OpenAIRE |
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