Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii
| Autor: | Bang-Jau You, Wen-Te Chang, Yueh-Hsiung Kuo, Louis Kuoping Chao, Sheng-Yang Wang, Guan-Jhong Huang, Yu-Chang Chen, Yen-Cheng Li, Lee-Chiang Lo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Lipopolysaccharides
medicine.drug_class Stereochemistry Cell Survival Anti-Inflammatory Agents Drug Evaluation Preclinical Pharmaceutical Science diterpenoid Nitric Oxide Anti-inflammatory Article Cunninghamia konishii Analytical Chemistry Cell Line lcsh:QD241-441 chemistry.chemical_compound Inhibitory Concentration 50 Mice lcsh:Organic chemistry Drug Discovery medicine Ic50 values Animals konishone Physical and Theoretical Chemistry No production Nitrite 3b-hydroxy-5 6-dehydrosugiol Cunninghamia Taxodiaceae anti-inflammatory biology Traditional medicine Macrophages Organic Chemistry 7 20-dinorabietane biology.organism_classification Wood Terpenoid chemistry Chemistry (miscellaneous) 3β-hydroxy-5 6-dehydrosugiol Molecular Medicine Diterpene Diterpenes |
| Zdroj: | Molecules; Volume 18; Issue 1; Pages: 682-689 Molecules Molecules, Vol 18, Iss 1, Pp 682-689 (2013) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules18010682 |
| Popis: | Two new diterpenoids, konishone (1) and 3b-hydroxy-5,6-dehydrosugiol (2), along with three known diterpenoids—hinokiol (3), sugiol (4), and 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (5)—were isolated from the wood of Cunninghamia konishii. Compound 1 is a novel skeleton of the 7,20-dinorabietane-type diterpene. In addition, when RAW264.7 macrophages were treated with different concentrations of compounds 1, 3, and 5 together with LPS, a significant concentration-dependent inhibition of NO production was detected. The IC50 values for inhibition of nitrite production of compounds 1, 3, and 5 were about 9.8 ± 0.7, 7.9 ± 0.9, and 9.3 ± 1.3 μg/mL, respectively. This study presents the potential utilization of compounds 1, 3, and 5, as lead compounds for the development of anti-inflammatory drugs. |
| Databáze: | OpenAIRE |
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