Alteration of T cell function in healthy persons with a history of thymic x-irradiation
| Autor: | Christian H.L. Rieger, Richard M. Rothberg, Sumner C. Kraft |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male Adolescent T-Lymphocytes Lymphocyte T cell Immunology Vaccinia virus Thymus Gland Biology Tuberculin Virus Mitomycins Immune system Lectins Candida albicans medicine Humans Immunology and Allergy Lymphocytes Chronic mucocutaneous candidiasis Child Skin Tests Immunity Cellular X-Rays Infant Streptodornase and Streptokinase biology.organism_classification medicine.disease Radiation Effects medicine.anatomical_structure Lymphatic system Child Preschool biology.protein Female Lymphocyte Culture Test Mixed Antibody |
| Zdroj: | Journal of Allergy and Clinical Immunology. 56:273-281 |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/0091-6749(75)90101-3 |
| Popis: | The possible late effects of x-irradiation to the infantile thymus were investigated by studying immune functions in 12 healthy persons with a history of thymic x-irradiation and healthy control subjects. No differences were found in serum immunoglobulin values, humoral antibody levels, lymphocyte counts, and lymphocyte reactivity to phytohemagglutinin, vaccinia virus, purified protein derivative (PPD), and allogeneic cells. The irradiation group exhibited cellular hyperresponsiveness to streptokinase-streptodornase (SK-SD). In contrast, mean skin and in vitro lymphocyte responses to Candida albicans were depressed in the patients with thymic irradiation. A dissociation of these two Candida responses was found in only 1 of 14 healthy control subjects but m 7 of 12 irradiated individuals. While thymic irradiation did not result in impaired immunologic defenses leading to clinical disease, it caused alterations in T cell responses similar to those reported in patients with chronic mucocutaneous candidiasis. |
| Databáze: | OpenAIRE |
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