'In vitro' effect of interleukin-1 beta on human glioma cell lines: regulation of cell proliferation and IL-6 production
| Autor: | Jean Willems, Sarah Cinque, Marcel Joniau, Stany Depraetere, Lea Vermeire |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
DNA Replication
medicine.medical_specialty medicine.medical_treatment Immunology Internal medicine Glioma medicine Cyclic AMP Tumor Cells Cultured Immunology and Allergy Humans Interleukin 6 biology Cell growth Interleukin-6 Interleukin medicine.disease In vitro Cell biology Endocrinology Cytokine medicine.anatomical_structure Bucladesine Cell culture biology.protein Cell Division Astrocyte Interleukin-1 Signal Transduction |
| Zdroj: | Immunology letters. 34(3) |
| ISSN: | 0165-2478 |
| Popis: | The human glioma cell lines U251 and HP591 were chosen as “in vitro” models for functional astrocytes. When cultured in the presence of IL-1β these cell lines demonstrated a marked increase in interleukin-6 production and in [ 3 H]-thymidine uptake. The addition of dbcAMP could mimick the first effect of IL-1β but at the same time suppressed cell proliferation. These results suggest that IL-1β possibly exerts one of its biological effects (IL-6 synthesis) by means of the cyclic AMP pathway. |
| Databáze: | OpenAIRE |
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