Food for thought: a critique on the hypothesis that endogenous cholecystokinin acts as a physiological satiety factor
| Autor: | I.S Ebenezer, B.A Baldwin, Parrott Rf |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Molecular Sequence Data Endogeny Vagotomy Blood–brain barrier digestive system Satiety Response Internal medicine medicine Animals Humans Amino Acid Sequence Receptor Cholecystokinin General Neuroscience digestive oral and skin physiology Brain Feeding Behavior Small intestine Vagus nerve medicine.anatomical_structure Endocrinology Blood-Brain Barrier Receptors Cholecystokinin Psychology Neuroscience hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Progress in neurobiology. 55(5) |
| ISSN: | 0301-0082 |
| Popis: | This review evaluates the various lines of evidence supporting the hypothesis that cholecystokinin (CCK) released from the small intestine during feeding plays a physiological role in mediating satiety. Issues considered include, the effects of systemic injection of CCK on consummatory and operant feeding, the role of the vagus nerve, the effects of CCK A and CCK B receptor antagonists, and the neuroendocrine responses to exogenous CCK. A critical appraisal of this research indicates that while it is clearly demonstratable that exogenous peripheral CCK can alter food intake by acting on CCK A receptors, the mechanism involved may be more closely related to the induction of aversion and nausea, rather than satiety. With regard to peripheral endogenous CCK, the available evidence also does not seem to support a role for the hormone in satiety. In particular, it is doubtful whether plasma concentrations of CCK following a meal are sufficiently high to inhibit feeding. Moreover, CCK A receptor antagonists which do not cross the blood brain barrier fail to increase meal size, as would be expected if peripheral CCK was an effective satiety factor. In addition, the recent literature concerned with the possibility that CCK may have a direct action within the brain in the control of food intake has been reviewed. These studies show that CCK adminstered intracerebroventicularly, or by micoinjection into discrete brain regions, also inhibits feeding via a CCK A receptor mechanism. However, the physiological relevance of these findings have yet to be determined. |
| Databáze: | OpenAIRE |
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