Trefoil factor peptide 3 is positively correlated with the viscoelastic properties of the cervical mucus plug
| Autor: | Peter Stubbe, Ioannis S. Chronakis, Lea Kirstine Hansen, Ebba Nexo, Sara Kjær Bastholm, Naja Becher, Niels Uldbjerg, Mie Hesselund Samson |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Pathology medicine.medical_specialty Enzyme-Linked Immunosorbent Assay Peptide Viscoelasticity Andrology Young Adult 03 medical and health sciences 0302 clinical medicine cervical mucus plug Pregnancy Elastic Modulus Humans Medicine Least-Squares Analysis Elastic modulus Trefoil Cervical canal viscoelasticity chemistry.chemical_classification Viscosity business.industry Obstetrics and Gynecology General Medicine Active Labor Mucus Cervical mucus plug 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis trefoil factor peptides1-3 Cervix Mucus Female rheology pregnancy Trefoil Factor-3 business |
| Zdroj: | Bastholm, S K, Samson, M H, Becher, N, Hansen, L K, Stubbe, P R, Chronakis, I S, Nexo, E & Uldbjerg, N 2017, ' Trefoil factor peptide 3 is positively correlated with the viscoelastic properties of the cervical mucus plug ', Acta Obstetricia et Gynecologica Scandinavica, vol. 96, no. 1, pp. 47-52 . https://doi.org/10.1111/aogs.13038 Bastholm, S K, Samson, M H, Becher, N, Hansen, L K, Stubbe, P R, Chronakis, I S, Nexo, E & Uldbjerg, N 2017, ' Trefoil factor peptide 3 is positively correlated with the viscoelastic properties of the cervical mucus plug ', Acta Obstetricia et Gynecologica Scandinavica, vol. 961, no. 1, pp. 47–52 . https://doi.org/10.1111/aogs.13038 |
| Popis: | INTRODUCTION: The viscoelastic properties of the cervical mucus plug are considered essential for the occlusion of the cervical canal and thereby for protection against ascending infections during pregnancy. Factors controlling this property are virtually unknown. This study explores a possible role of trefoil factor peptides 1, 2 and 3 (TFF1-3); peptides believed to influence mucus viscosity.MATERIALS AND METHODS: The study is based on spontaneously shed cervical mucus plugs from 14 women in active labor. The viscoelastic properties; the elastic modulus (G') and the viscous modulus (G'') were determined by an oscillatory rheometer. The concentrations of TFF1-3 were measured by an in-house ELISA. Associations were analyzed by random-effects generalized least squares regression analyses.RESULTS: Median (range) concentrations of TFF1, (TFF2) and [TFF3] were 3.1 (1.2-8.6), (1.1 (CONCLUSION: We suggest that TFF3 plays a role for the viscoelastic properties of cervical mucus plug. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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