HLA antibodies—the cause of platelet alloimmunization in chinese
| Autor: | Mo-Ping Chow, Wen-Mei Lin, Chung-King Lin, Jaw-Lin Tzeng, Chien-Hui Yung, Hui-Yu Hu, Jeong-Shi Lin |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Adolescent Taiwan Fluorescent Antibody Technique Human leukocyte antigen Immunofluorescence Antibodies ABO Blood-Group System Asian People Antibody Specificity HLA Antigens Isoantibodies Blood product medicine Humans Antigens Human Platelet Hla antibodies Platelet Child Aged Antilymphocyte Serum medicine.diagnostic_test biology business.industry Hematology Middle Aged Platelet transfusion Child Preschool Antibody Formation Immunology biology.protein Female Antibody Complication business |
| Zdroj: | American Journal of Hematology. 39:15-19 |
| ISSN: | 1096-8652 0361-8609 |
| Popis: | Lymphocytotoxicity test (LCT) and platelet suspension immunofluorescence test (PSIFT) were used together to screen platelet-associated antibodies in patients who received long-term platelet transfusion. Twenty-four of 53 patients (45.3%) were immunized subsequently. Since the concordance of LCT and PSIFT was 100%, most of the platelet associated antibodies were of HLA specificity, and platelet specific antibody alone (in absence of HLA) was not detected. The identified antibodies were anti-A2, A11, A24, B5, B46, B57, B60, and B62. The majority of them were against the high frequency HLA antigens in the Chinese population. The development of antibody could not be correlated with the number of platelet-donors exposed, the time interval after the initiation of platelet transfusion, or the percentage of reactive lymphocytotoxic panels. HLA antibody was the major factor in causing platelet alloimmunization in the Chinese patients. However, some other unknown factors should be looked for. In addition, ABO incompatibility did not affect the posttransfusional increment while the platelet was compatible with LCT crossmatching. |
| Databáze: | OpenAIRE |
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