Phototriggered Local Anesthesia
| Autor: | James B. Mcalvin, Daniel S. Kohane, Claudia M. Santamaria, Shutao Guo, Changyou Zhan, Weiping Wang, Brian P. Timko |
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| Rok vydání: | 2015 |
| Předmět: |
Agonist
Light medicine.drug_class Bioengineering 02 engineering and technology Tetrodotoxin 010402 general chemistry 01 natural sciences chemistry.chemical_compound Sodium channel blocker Drug Delivery Systems In vivo medicine Animals Humans General Materials Science Local anesthesia Dexmedetomidine Liposome Nanotubes Mechanical Engineering General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Rats chemistry Toxicity Liposomes Gold 0210 nano-technology Biomedical engineering medicine.drug Anesthesia Local |
| Zdroj: | Nano letters. 16(1) |
| ISSN: | 1530-6992 |
| Popis: | We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), enabling light-triggered phase transition of their lipid bilayers with a consequent release of payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin and the α2-adrenergic agonist dexmedetomidine (Lip-GNR-TD) were injected subcutaneously in the rat footpad. Irradiation with an 808 nm continuous wave NIR laser produced on-demand and repeated infiltration anesthesia in the rat footpad in proportion to the irradiance, with minimal toxicity. The ability to achieve on-demand and repeated local anesthesia could be very beneficial in the management of pain. |
| Databáze: | OpenAIRE |
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