Forging the endothelium during inflammation: pushing at a half-open door?
| Autor: | Beat A. Imhof, Caroline Johnson-Leger |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Histology
Endothelium Inflammatory response Inflammation Cell Communication ddc:616.07 Pathology and Forensic Medicine Capillary Permeability Cell Movement Cell Adhesion Leukocytes medicine Animals Humans Intercellular Junctions/ physiology Leukocytes/physiology Cell adhesion molecule Chemistry Cell Biology Cell biology Intercellular Junctions medicine.anatomical_structure Endothelium Vascular/cytology/ physiology Immunology Endothelium Vascular medicine.symptom Cell Adhesion Molecules/ physiology Cell Adhesion Molecules Signal Transduction |
| Zdroj: | Cell and Tissue Research, Vol. 314, No 1 (2003) pp. 93-105 |
| ISSN: | 1432-0878 0302-766X |
| DOI: | 10.1007/s00441-003-0775-4 |
| Popis: | During an inflammatory response, changes in the adhesive properties of the endothelium occur that enable normally non-adherent blood-borne leukocytes to adhere and subsequently to traverse the endothelium through small gaps at inter-cellular junctions. This review concentrates on the role played by inter-endothelial adhesion molecules during transmigration and the way in which their expression may be regulated during inflammation. We show that the final "open" signals that lead to the formation of clefts between adjacent endothelial cells may be derived from inflamed tissue underlying the endothelium and from activated leukocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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