Synthesis and crystal structures of phenylalanine ester-introduced palladium(II) and platinum(II) complexes and their cytotoxicities
| Autor: | Akiya Ogawa, Akihiro Nomoto, Shun-ichiro Ogura, Katao Shouhei, Jun-ichi Kikuchi, Nozomi Sakamoto, Yuta Sakai, Keisuke Fukumoto, Kiyomi Kakiuchi, Shigenobu Yano |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Chemistry chemistry.chemical_element Phenylalanine General Chemistry Crystal structure Amino acid Catalysis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Polymer chemistry Moiety Cytotoxicity Platinum Palladium |
| Zdroj: | Research on Chemical Intermediates. 45:3-12 |
| ISSN: | 1568-5675 0922-6168 |
| DOI: | 10.1007/s11164-018-3623-6 |
| Popis: | Phenylalanine ester-introduced palladium(II) and platinum(II) complexes were synthesized. Taking advantage of the formation of Schiff bases by amino acids as an intermediate, the pyridylimine moiety coordinated to a metal center. Single crystals of each complex were obtained successfully, and their molecular structures were clarified in detail. The Pd(II) complex showed remarkable cytotoxicity compared to the Pt(II) complex. |
| Databáze: | OpenAIRE |
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