Gut microbiota in children and altered profiles in juvenile idiopathic arthritis
| Autor: | Carlotta De Filippo, Rolando Cimaz, Monica Di Paola, Francesca Tirelli, Teresa Giani |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Immunology Arthritis Inflammation Gut microbiota Gut flora digestive system Autoimmune disease Juvenile idiopathic arthritis Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system medicine Immunology and Allergy Homeostasis Humans Child Symbiosis 030203 arthritis & rheumatology biology biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Inflammatory Bowel Diseases Arthritis Juvenile Gastrointestinal Microbiome 030104 developmental biology Immune System Dysbiosis Bacterial antigen medicine.symptom |
| Zdroj: | Journal of autoimmunity 98 (2019): 1–12. doi:10.1016/j.jaut.2019.01.001 info:cnr-pdr/source/autori:De Filippo, Carlotta; Di Paola, Monica; Giani, Teresa; Tirelli, Francesca; Cimaz, Rolando/titolo:Gut microbiota in children and altered profiles in juvenile idiopathic arthritis/doi:10.1016%2Fj.jaut.2019.01.001/rivista:Journal of autoimmunity (Print)/anno:2019/pagina_da:1/pagina_a:12/intervallo_pagine:1–12/volume:98 |
| ISSN: | 1095-9157 |
| DOI: | 10.1016/j.jaut.2019.01.001 |
| Popis: | Microbial diversity plays a key role in the maintenance of intestinal homeostasis and in the development of the immune system in the gut mucosa. Maybe one of the most important function of our gut microbiota is the immune system education, in particular the discrimination of friends from foes that occurs during childhood. In addition to bacterial antigens, several metabolites of microbial origin have a crucial role in training of the immune system, such as Short Chain Fatty Acids (SCFAs). There are many evidences on the role of the gut microbiota in rheumatic diseases, in particular modifications of microbiota composition causing dysbiosis that, in turn, can induce gut permeability, and thus immunological imbalance and trigger inflammation. In particular, immune cells can reach extra-intestinal sites, such as joints and trigger local inflammation. Childhood is a crucial period of life for development and evolution of the gut microbiota, especially for the acquisition of fundamental functions such as immunotolerance of commensal microorganisms. For this reason, gut dysbiosis is gaining interest as a potential pathogenetic factor for Juvenile Idiopathic Arthritis (JIA). Here we summarized the studies conducted on JIA patients in which a pro-arthritogenic microbial profiles has been observed; this, together with a depletion of microbial biodiversity, clearly distinguish patients' from healthy subjects' microbiota. Further studies are however needed to better clarify the role of microbiota in JIA pathogenesis. |
| Databáze: | OpenAIRE |
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