Inflammation and Stress Biomarkers Mediate the Relationship Between Household Food Insecurity and Insulin Resistance Among Latinos with Type 2 Diabetes (OR02-02-19)
| Autor: | Grace Damio, Angela Bermudez-Millan, Sofia Segura-Pérez, Julie Wagner, Jyoti Chhabra, Richard Feinn, Rafael Pérez-Escamilla |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nutrition and Dietetics
biology business.industry Insulin medicine.medical_treatment Stressor C-reactive protein Medicine (miscellaneous) Inflammation Type 2 diabetes medicine.disease Community and Public Health Nutrition Insulin resistance Environmental health medicine biology.protein medicine.symptom business Food Science Hydrocortisone medicine.drug Hormone |
| Popis: | OBJECTIVES: Household food insecurity (HFI) is a stressor that is associated with hyperglycemia type 2 diabetes (T2D). However, little is known about HFI and the insulin resistance underlying hyperglycemia and T2D, and mechanisms involved have not been elucidated. We examined HFI and insulin resistance among low-income Latinos with T2D and tested whether inflammation and stress hormones mediated this relationship. METHODS: This study is cross-sectional. HFI was measured with the Spanish and English versions of the 6-item US Household Food Security Survey Module. Insulin resistance was calculated from fasting blood glucose and insulin. Inflammation was indicated by high-sensitivity C-reactive protein, and stress hormones included cortisol, metanephrine and normetanephrine. RESULTS: The 121 participants were primarily Puerto Rican (85.8%), aged mean = 60.7 years and 74% were female. Eighty-two (68%) were classified as food insecure. Compared to food secure individuals, food insecure individuals had a significantly higher hsCRP (P = .008), cortisol (P = .045), insulin (P = .019), glucose (P |
| Databáze: | OpenAIRE |
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