Feasibility evaluation of a Cu-38 Zn alloy for intrauterine devices: In vitro and in vivo studies
| Autor: | Qianqian Fan, Guo Bao, Xiaoxue Xu, Liquan Zhu, Xiangbo Xu, Zechuan Zhang, Yufeng Zheng, Tingting Liu, Guannan Li, Bin He, Lijun Yang, Xihua Chen, Kun Wang |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Stromal cell
Biocompatibility Alloy Biomedical Engineering chemistry.chemical_element engineering.material Biochemistry Corrosion Biomaterials In vivo Alloys Humans Cytotoxicity Molecular Biology Chemistry General Medicine Intrauterine Devices Copper Copper In vitro Zinc engineering Feasibility Studies Female Biotechnology Nuclear chemistry |
| Zdroj: | Acta Biomaterialia. 138:561-575 |
| ISSN: | 1742-7061 |
| DOI: | 10.1016/j.actbio.2021.11.006 |
| Popis: | The existing adverse effects of copper in copper-containing intrauterine devices (Cu-IUDs) have raised concerns regarding their use. These adverse effects include burst release of cupric ions (Cu2+) at the initial stage and an increasingly rough surface of the Cu-IUDs. In this study, we investigated the use of two copper alloys, Cu-38Zn and H62 as the new upgrading or alternative material for IUDs. Their corrosive properties were studied in simulated uterine fluid (SUF) by using electrochemical methods, with pure Cu as a control. We studied the in vitro long-term corrosion behaviors in SUF, cytotoxicity to uterine cells (human endometrial epithelial cells and human endometrial stromal cells), in vivo biocompatibility and contraceptive efficacy of pure Cu, H62, and Cu-38Zn. In the first month, the burst release rate of Cu2+ in the Cu-38Zn group was significantly lower than those in the pure Cu and H62 groups. The in vitro cytocompatibility Cu-38Zn was better than that of pure Cu and H62. Moreover, Cu-38Zn showed improved tissue biocompatibility in vivo experiments. Therefore, the contraceptive efficacy of the Cu-38Zn is still maintained as high as the pure Cu while the adverse effects are significantly eased, suggesting that Cu-38Zn can be a suitable potential candidate material for IUDs. STATEMENT OF SIGNIFICANCE: The existing adverse effects associated with the intrinsic properties of copper materials for copper-containing intrauterine devices (Cu-IUD) are of concern in their employment. Such as, burst release of cupric ions (Cu2+) at the initial stage and an increasingly rough surface of the Cu-IUD. In this work, Cu alloyed with a high amount of bioactive Zn was used for a Cu-IUD. The Cu-38Zn alloy exhibited reduced burst release of Cu2+ within the first month compared with the pure Cu and H62. Furthermore, the Cu-38Zn alloy displayed significantly improved biocompatibility and a much smoother surface. Therefore, high antifertility efficacy of the Cu-38Zn alloy was well maintained, while the adverse effects are significantly eased, suggesting that the Cu-38Zn alloy is promising for a Cu-IUD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect