Biomechanical properties and microscopic morphology of human stratum corneum incubated on a wet pad in vitro
| Autor: | R. Laurent, Pierre Agache, Jean Pierre Boyer |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Adult
Male Controlled atmosphere Adolescent Analytical chemistry Dermatology In Vitro Techniques In vivo Stratum corneum medicine Methods Humans Relative humidity Microscopic morphology Skin Cement Chemistry Humidity General Medicine Desmosomes In vitro Microscopy Electron medicine.anatomical_structure Intercellular Junctions Biophysics Stress Mechanical Elongation |
| Zdroj: | Archiv fur dermatologische Forschung. 246(3) |
| ISSN: | 0003-9187 |
| Popis: | Samples of human Stratum corneum (St. c.) collected by the cantharidin method and suspended in a controlled atmosphere usually show a raised extensibility when the relative humidity (RH) is raised, and, consequently, a greater solidity. When the St. c. samples were not suspended but laid on a wet pad, extensibility did not change when RH was raised, but elongation decreased owing to a strong reduction of breaking strength; the St. c. became more fragile. Electron and optical microscopic studies revealed that this latter phenomenon was due to an alteration of the links between cells, i. e. cell interlockings, desmosomes, intercellular cement. In this experiment, St. c. samples were not stiff as when suspended in air, but supple as in vivo; the technics provide a good model for in vivo hyperhydrated St. c. |
| Databáze: | OpenAIRE |
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