Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers
| Autor: | Thorbecke Gj, David Lo, Norman R. Klinman, Lai L, Phyllis-Jean Linton |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Immunology Population chemical and pharmacologic phenomena Spleen Mice SCID Biology CD5 Antigens Mice Antigens CD Precursor cell medicine Immunology and Allergy Animals Progenitor cell education education.field_of_study B-Lymphocytes Mice Inbred BALB C CD40 Histocompatibility Antigens Class II Germinal center Hematopoietic Stem Cells Cell biology medicine.anatomical_structure Immunization biology.protein CD5 Immunologic Memory |
| Zdroj: | European journal of immunology. 22(5) |
| ISSN: | 0014-2980 |
| Popis: | Immunization leads to the generation of both antibody-forming cells (AFC) and memory B cells which are thought to arise in germinal centers within lymphoid follicles. The findings that the precursors to memory B cells reside in the J11Dlo subpopulation of the spleens in non-immune mice and that this subpopulation is distinct from conventional AFC precursors, including CD5+ B cells, suggest that the precursors of germinal centers might also reside in the J11Dlo subpopulation. To test this hypothesis, SCID mice were repopulated with CD4+ carrier-primed T cells and T-depleted J11Dlo, J11Dhi or CD5+ B cells and immunized with a hapten-carrier conjugate. Only the J11Dlo population was enriched for cells that produced germinal centers. Thus, the subpopulation of precursors that generates memory B cells also originates germinal centers. |
| Databáze: | OpenAIRE |
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