Association Between Migraine and Cervical Artery Dissection The Italian Project on Stroke in Young Adults
| Autor: | Cristiano Azzini, Valeria De Giuli, Andrea Zini, Lucia Tancredi, Giovanni Malferrari, Davide Massucco, Nicoletta Checcarelli, Maurizio Melis, A. Spalloni, Giorgio Silvestrelli, Marialuisa Zedde, Paola Ferrazzi, Giampaolo Tomelleri, Domenico Marco Bonifati, Alessandro De Vito, Filomena Di Lisi, Masina Cotroneo, Valeria Piras, Giuseppe Micieli, Elisa Coloberti, Rosalba Patella, Maria Luisa DeLodovici, Rocco Salvatore Calabrò, Andrea Morotti, Alessandro Pezzini, Licia Iacoviello, Mario Grassi, Alessandro Adami, Loris Poli, Giacomo Giacalone, Enrico Maria Lotti, Carlo Gandolfo, Alessandro Padovani, Maurizia Rasura, Paolo Cerrato, Corrado Lodigiani, Filomena Caria, R. Musolino, Elisabetta Del Zotto, Anna Cavallini, Paolo Bovi, Elisa Giorli, Simona Marcheselli, Antonella Toriello, Paolo Costa, Anna Maria Simone, Massimo Gamba, Laura Cucurachi, Maria Sessa, Maurizio Paciaroni, Alessia Giossi, Cataldo D'Amore, Ilaria Casetta, Alessia Lanari, Alberto Chiti, Massimo Del Sette |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Migraine without Aura Aura Migraine with Aura 030204 cardiovascular system & hematology Brain Ischemia 0302 clinical medicine Prospective Studies Registries Young adult Prospective cohort study Stroke Vertebral Artery Dissection Age Factors Middle Aged Digital Subtraction Angiography Carotid Arteries Italy Anesthesia Female medicine.symptom Adult medicine.medical_specialty Adolescent Artery dissection Young stroke Migraine Young stroke Socio-culturale Case-Control Studies Humans Intracranial Arterial Diseases Sex Factors Young Adult Vertebral Artery Dissection Carotid Arteries Digital Subtraction Angiography 03 medical and health sciences Internal medicine Diabetes mellitus Artery dissection medicine cervical artery dissection Migraine business.industry Case-control study medicine.disease Migraine with aura Neurology (clinical) business 030217 neurology & neurosurgery migraine |
| Popis: | Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association between the 2 disorders is still unconfirmed. This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditions and the complex relationship between migraine and ischemic stroke (IS).To investigate whether a history of migraine and its subtypes is associated with the occurrence of CEAD.A prospective cohort study of consecutive patients aged 18 to 45 years with first-ever acute ischemic stroke enrolled in the multicenter Italian Project on Stroke in Young Adults was conducted between January 1, 2000, and June 30, 2015. In a case-control design, the study assessed whether the frequency of migraine and its subtypes (presence or absence of an aura) differs between patients whose IS was due to CEAD (CEAD IS) and those whose IS was due to a cause other than CEAD (non-CEAD IS) and compared the characteristics of patients with CEAD IS with and without migraine.Frequency of migraine and its subtypes in patients with CEAD IS vs non-CEAD IS.Of the 2485 patients (mean [SD] age, 36.8 [7.1] years; women, 1163 [46.8%]) included in the registry, 334 (13.4%) had CEAD IS and 2151 (86.6%) had non-CEAD IS. Migraine was more common in the CEAD IS group (103 [30.8%] vs 525 [24.4%], P = .01), and the difference was mainly due to migraine without aura (80 [24.0%] vs 335 [15.6%], P .001). Compared with migraine with aura, migraine without aura was independently associated with CEAD IS (OR, 1.74; 95% CI, 1.30-2.33). The strength of this association was higher in men (OR, 1.99; 95% CI, 1.31-3.04) and in patients 39.0 years or younger (OR, 1.82; 95% CI, 1.22-2.71). The risk factor profile was similar in migrainous and non-migrainous patients with CEAD IS (eg, hypertension, 20 [19.4%] vs 57 [24.7%], P = .29; diabetes, 1 [1.0%] vs 3 [1.3%], P .99).In patients with IS aged 18 to 45 years, migraine, especially migraine without aura, is consistently associated with CEAD. This finding suggests common features and warrants further analyses to elucidate the underlying biologic mechanisms. |
| Databáze: | OpenAIRE |
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