Impact of Smoking, Obesity and Maternal Diabetes on SHBG Levels in Newborns
| Autor: | Beril Yasa, Stephen J. Winters, Banu Kucukemre Aydin, Feyza Darendeliler, Sukran Poyrazoglu, Firdevs Bas, Cenk Yasa, Asuman Coban, Joseph P. Moore |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Sex hormone-binding globulin Insulin resistance Pregnancy Diabetes mellitus Internal Medicine medicine Birth Weight Humans 030212 general & internal medicine Longitudinal Studies Obesity biology business.industry Obstetrics Insulin Smoking Infant Newborn General Medicine medicine.disease Diabetes Gestational Cross-Sectional Studies biology.protein Female medicine.symptom Metabolic syndrome business Weight gain Biomarkers |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 130(5) |
| ISSN: | 1439-3646 |
| Popis: | Low levels of SHBG have become a marker for insulin resistance and diabetes. Babies born to mothers who are obese, have diabetes, or smoke during pregnancy are at greater risk of developing obesity and diabetes later in life.To examine the impact of maternal obesity, diabetes and smoking on SHBG levels in newborns.This cross-sectional study is part of an ongoing multicenter, longitudinal study.98 healthy newborns and their parents, including 16 mothers with diabetes and 31 mothers with a smoking history.Cord blood and second day venipuncture samples were collected for measurement of SHBG and insulin.Babies born to mothers with diabetes had lower SHBG levels in cord blood [14.0 (8.9-20.4) vs. 19.6 (14.9-25.1) nmol/L; p=0.011] and on day 2 [18.8 (12.6-21.2) vs. 22.9 (17.1-29.1) nmol/L; p=0.015] than controls. Maternal diabetes remained negatively associated with SHBG levels in cord blood (p=0.02) and on day 2 (p=0.04) when adjusted for mothers' age, smoking status, pre-pregnancy weight and weight gain during pregnancy. SHBG levels in cord blood and day 2 samples were similar in babies born to mothers who were overweight-obese but not diabetic vs. normal weight, or were smokers when compared to non-smokers.SHBG levels are lower in newborns born to mothers with diabetes than without diabetes, and may be a marker for babies' life-long risk for abnormal metabolic health. On the other hand, the adverse effects of tobacco smoke on the fetus do not appear to directly influence SHBG levels.Low levels of SHBG have become a marker for insulin resistance and diabetes. Babies born to mothers who are obese, have diabetes, or smoke during pregnancy are at greater risk of developing obesity and diabetes later in life.To examine the impact of maternal obesity, diabetes and smoking on SHBG levels in newborns.This cross-sectional study is part of an ongoing multicenter, longitudinal study.98 healthy newborns and their parents, including 16 mothers with diabetes and 31 mothers with a smoking history.Cord blood and second day venipuncture samples were collected for measurement of SHBG and insulin.Babies born to mothers with diabetes had lower SHBG levels in cord blood [14.0 (8.9–20.4) vs. 19.6 (14.9–25.1) nmol/L; p=0.011] and on day 2 [18.8 (12.6–21.2) vs. 22.9 (17.1–29.1) nmol/L; p=0.015] than controls. Maternal diabetes remained negatively associated with SHBG levels in cord blood (p=0.02) and on day 2 (p=0.04) when adjusted for mothers’ age, smoking status, pre-pregnancy weight and weight gain during pregnancy. SHBG levels in cord blood and day 2 samples were similar in babies born to mothers who were overweight-obese but not diabetic vs. normal weight, or were smokers when compared to non-smokers.SHBG levels are lower in newborns born to mothers with diabetes than without diabetes, and may be a marker for babies’ life-long risk for abnormal metabolic health. On the other hand, the adverse effects of tobacco smoke on the fetus do not appear to directly influence SHBG levels. |
| Databáze: | OpenAIRE |
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