Cofactors in human papillomavirus infection and cervical carcinogenesis
| Autor: | Ferit Soylu, Hakan Yetimalar, Askin Yildiz, Külal Çukurova, Burcu Kasap, Adnan Keklik |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Adolescent Population Sexually Transmitted Diseases Uterine Cervical Neoplasms medicine.disease_cause Bioinformatics Uterine Cervical Diseases Young Adult Risk Factors Prevalence Humans Medicine Cervix neoplasm Young adult education Aged Cervical cancer education.field_of_study business.industry Carcinoma Papillomavirus Infections Smoking HPV infection virus diseases Obstetrics and Gynecology Cancer General Medicine Middle Aged medicine.disease Virology female genital diseases and pregnancy complications Human genetics Parity Cell Transformation Neoplastic Contraception Sexual Partners Female Warts business Carcinogenesis |
| Zdroj: | Archives of Gynecology and Obstetrics. 285:805-810 |
| ISSN: | 1432-0711 0932-0067 |
| Popis: | This study aimed to identify the effect of various risk factors as the promoters of HPV infection, and to identify which HPV-positive women may have an increased risk of developing cervical cancer.Smear preparations were examined and classified according to the Bethesda system. HPV-DNA detection and genotyping was carried out using polymerase chain reaction combined with reverse hybridization line-probe assays. Age, smoking habit, age at first sexual intercourse, number of sexual partners, number of term births, contraceptive method, progesterone therapy, history of sexually transmitted diseases, history or existence of warts and existence of cervical infection were recorded.642 women (96 women with abnormal cervical cytology and 546 women with normal cytology) provided cervical samples. Smoking habit, number of sexual partners, number of term births, history of sexually transmitted diseases, history or existence of warts and existence of cervical infection were identified as the promoters of HPV infection. History of sexually transmitted diseases, history or existence of warts and existence of cervical infection were identified as cofactors affecting progression from HPV infection to cervical cancer. Neither of contraceptive methods studied was related to HPV infection or coexistence with malign transformation to cervical cancer.Information gathered from this study could be used to prioritize limited screening and treatment services to woman who have specific characteristics that may put them at an increased risk of HPV infection. Additionally, by identifying which women have a higher risk of cervical cancer; it may be possible to reduce the number of unnecessary colposcopies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink