Effect of Clonidine on Renal Sodium Handling in Spontaneously Hypertensive Rats
| Autor: | Maria Augusta Vieira-Coelho, Eduardo Moura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Sodium Potassium chemistry.chemical_element Blood Pressure Kidney Body weight Rats Inbred WKY Clonidine Norepinephrine Heart Rate Rats Inbred SHR Internal medicine Adrenergic alpha-2 Receptor Agonists medicine Animals cardiovascular diseases Pharmacology business.industry lcsh:RM1-950 Kidney metabolism musculoskeletal system Rats medicine.anatomical_structure Endocrinology Blood pressure lcsh:Therapeutics. Pharmacology chemistry Renal sodium excretion Creatinine Hypertension cardiovascular system Molecular Medicine business medicine.drug circulatory and respiratory physiology |
| Zdroj: | Journal of Pharmacological Sciences, Vol 119, Iss 2, Pp 122-130 (2012) |
| ISSN: | 1347-8613 |
| Popis: | Up-regulation of kidney α2-adrenoceptor expression has been implicated in the development of hypertension in spontaneously hypertensive rats (SHR). This study was carried out to evaluate renal sodium excretion in response to clonidine administration in SHR and control normotensive Wistar-Kyoto (WKY) rats. SHR and WKY rats (12-week-old) were placed in metabolic cages for 4 days: the first 2 days in control conditions and the following 2 days under oral clonidine treatment (100 μg/kg body weight). Clonidine produced a similar reduction in systolic blood pressure values in SHR and WKY rats, although SHR remained hypertensive. At the end of the study SHR and WKY rats presented similar noradrenaline plasma levels. However, noradrenaline kidney tissue levels were significantly higher in SHR compared to WKY rats. Under control conditions, SHR presented lower urine flow compared to WKY rats. Clonidine produced a significant decrease in urine flow in WKY rats but not in SHR. Furthermore, clonidine also produced a significant reduction in urinary sodium, potassium, and creatinine excretion in WKY rats, but had no effect in SHR. In conclusion, in SHR the reduction in systolic blood pressure and sympathetic activity produced by clonidine was not accompanied by a decrease in urine volume and sodium excretion. Keywords:: clonidine, spontaneously hypertensive rats (SHR), kidney, α2-adrenoceptor, sympathetic nervous system (SNS) |
| Databáze: | OpenAIRE |
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