Tumor detection using folate receptor-targeted imaging agents
| Autor: | Emanuela I. Sega, Philip S. Low |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Diagnostic Imaging
Cancer Research Pathology medicine.medical_specialty Receptors Cell Surface Endometrium Drug Delivery Systems Folic Acid Neoplasms medicine Animals Humans Receptor business.industry Folate Receptors GPI-Anchored Cancer medicine.disease Clinical trial Functional imaging Haematopoiesis medicine.anatomical_structure Oncology Folate receptor Cancer research Radiopharmaceuticals Molecular imaging Carrier Proteins business |
| Zdroj: | Cancer and Metastasis Reviews. 27:655-664 |
| ISSN: | 1573-7233 0167-7659 |
| DOI: | 10.1007/s10555-008-9155-6 |
| Popis: | Folate receptors are up-regulated on a variety of human cancers, including cancers of the breast, ovaries, endometrium, lungs, kidneys, colon, brain, and myeloid cells of hematopoietic origin. This over-expression of folate receptors (FR) on cancer tissues can be exploited to target folate-linked imaging and therapeutic agents specifically to FR-expressing tumors, thereby avoiding uptake by most healthy tissues that express few if any FR. Four folate-targeted therapeutic drugs are currently undergoing clinical trials, and several folate-linked chemotherapeutic agents are in late stage preclinical development. However, because not all cancers express FR, and because only FR-expressing cancers respond to FR-targeted therapies, FR-targeted imaging agents have been required to select patients with FR-expressing tumors likely to respond to folate-targeted therapies. This review focuses on recent advances in the use of the vitamin folic acid to target PET agents, gamma-emitters, MRI contrast agents and fluorescent dyes to FR(+) cancers for the purpose of diagnosing and imaging malignant masses with improved specificity and sensitivity. |
| Databáze: | OpenAIRE |
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