Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS
| Autor: | Graham McIlroy, Istvan Foldi, Jukka Aurikko, Jill S Wentzell, Mei Ann Lim, Janine C Fenton, Nicholas J Gay, Alicia Hidalgo |
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| Rok vydání: | 2013 |
| Předmět: |
Nervous system
Central Nervous System Embryo Nonmammalian receptor Animals Genetically Modified 0302 clinical medicine Drosophila Proteins Axon Receptor Cells Cultured Neurons axon 0303 health sciences biology General Neuroscience neurotrophin locomotor Gene Expression Regulation Developmental Eve medicine.anatomical_structure Drosophila melanogaster Larva Drosophila Lim3 CNS Drosophila Protein Locomotion Neurotrophin Protein Binding DNT1 DNT2 Green Fluorescent Proteins Nerve Tissue Proteins Receptors Nerve Growth Factor Transfection survival Article 03 medical and health sciences TLR medicine Animals RNA Messenger Toll 030304 developmental biology Innate immune system fungi biology.organism_classification neuron Toll-6 Toll-Like Receptor 6 HB9 nervous system Toll-Like Receptor 7 Toll-7 Trk receptor biology.protein Neuroscience 030217 neurology & neurosurgery NFκB |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 |
| Popis: | Neurotrophin receptors corresponding to vertebrate Trk, p75(NTR) or Sortilin have not been identified in Drosophila, thus it is unknown how neurotrophism may be implemented in insects. Two Drosophila neurotrophins, DNT1 and DNT2, have nervous system functions, but their receptors are unknown. The Toll receptor superfamily has ancient evolutionary origins and a universal function in innate immunity. Here we show that Toll paralogs unrelated to the mammalian neurotrophin receptors function as neurotrophin receptors in fruit flies. Toll-6 and Toll-7 are expressed in the CNS throughout development and regulate locomotion, motor axon targeting and neuronal survival. DNT1 (also known as NT1 and spz2) and DNT2 (also known as NT2 and spz5) interact genetically with Toll-6 and Toll-7, and DNT1 and DNT2 bind to Toll-6 and Toll-7 promiscuously and are distributed in vivo in domains complementary to or overlapping with those of Toll-6 and Toll-7. We conclude that in fruit flies, Tolls are not only involved in development and immunity but also in neurotrophism, revealing an unforeseen relationship between the neurotrophin and Toll protein families. |
| Databáze: | OpenAIRE |
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