Matrix metalloproteinases and E-cadherin immunoreactivity in different basal cell carcinoma histological types
| Autor: | Veljko Rogošić, Snježana Mardešić, Lucija Vanjaka-Rogošić, Mirna Saraga Babić, Lina Mirić, Ivana Kuzmić-Prusac, Neira Puizina-Ivić, Dubravka Vuković |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Stromal cell medicine.diagnostic_test Cadherin Cell Biology General Medicine Biology Matrix metalloproteinase medicine.disease Cadherins Immunohistochemistry Matrix Metalloproteinases Stroma Basal cell carcinoma MMP-1 MMP-2 MMP-9 MMP-13 E-cadherin Carcinoma Basal Cell Biopsy Multivariate Analysis medicine Humans Immunostaining |
| Popis: | The immunohistochemical staining of matrix metalloproteinases (MMPs) and E-cadherin in tumor epithelial and stromal cells was analyzed in a group of solid, superficial spreading and cystic tumors and in a group of morpheaform and recurrent basal cell carcinomas (BCC) in order to determine whether any of these factors possibly contribute to tumor therapy resistance. Tumor tissues of 64 patients were obtained by complete excisional or curettage biopsy of BCC and these were immunohistochemically stained for MMP-1, MMP-2, MMP-9, MMP-13 and E-cadherin. In the morpheaform and recurrent BCC, MMP-9 expression significantly increased in the stroma, while E-cadherin expression was negative in epithelial cells. Odds ratio for development of morpheaform and recurrent BCC was 6.2 for positive MMP-1 immunostaining in epithelial tumor cells, 5.8 for positive MMP-9 immunostaining in tumor stroma, 3.2 for positive MMP-13 immunostaining in tumor stroma, and 4.5 for negative E-cadherin in epithelial tumor cells. Our results suggest that MMP-1 immunostaining in tumor cells, MMP-9 expression in stromal cells, and absence of E-cadherin expression are associated with morpheaform and recurrent BCC. |
| Databáze: | OpenAIRE |
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