Utilizing Paper-Based Devices for Antimicrobial-Resistant Bacteria Detection
| Autor: | Charles S. Henry, Elizabeth P. Ryan, Brian J. Geiss, Jaclyn A. Adkins, Christopher R. Wheeldon, Amethyst V Holder, Jake Gilliand, Katherine E. Boehle |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiological Techniques Paper Antimicrobial resistant bacteria 030106 microbiology Colony Count Microbial Sewage 02 engineering and technology Wastewater 01 natural sciences Catalysis World health beta-Lactam Resistance Article 03 medical and health sciences Antibiotic resistance Environmental water biology Bacteria business.industry 010401 analytical chemistry Reproducibility of Results General Chemistry Paper based General Medicine Electrochemical Techniques 021001 nanoscience & nanotechnology Antimicrobial biology.organism_classification 0104 chemical sciences Biotechnology Anti-Bacterial Agents 030104 developmental biology Environmental science Colorimetry 0210 nano-technology business Water Microbiology beta-Lactamase Inhibitors |
| Zdroj: | Angewandte Chemie (International ed. in English). 56(24) |
| ISSN: | 1521-3773 |
| Popis: | Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents. Per the World Health Organization, AMR has an estimated annual cost of USD 34 billion in the US and is predicted to be the number one cause of death worldwide by 2050. One way AMR bacteria can spread, and by which individuals can contract AMR infections, is through contaminated water. Monitoring AMR bacteria in the environment currently requires that samples be transported to a central laboratory for slow and labor intensive tests. We have developed an inexpensive assay using paper-based analytical devices (PADs) that can test for the presence of β-lactamase-mediated resistance. To demonstrate viability, the PAD was used to detect β-lactam resistance in wastewater and sewage and identified resistance in individual bacterial species isolated from environmental water sources. |
| Databáze: | OpenAIRE |
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