Idiopathic short stature: Management and growth hormone treatment
| Autor: | Alan D. Rogol, Paul Saenger, Pinchas Cohen, Judith L. Ross, Jan M. Wit, Martin O. Savage, Edward O. Reiter |
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| Rok vydání: | 2008 |
| Předmět: |
Counseling
Pediatrics medicine.medical_specialty Sexual characteristics Endocrinology Diabetes and Metabolism Treatment outcome Endocrinology Age Determination by Skeleton Internal medicine medicine Humans Growth Disorders Clinical Trials as Topic Human Growth Hormone business.industry Puberty Final height Oxandrolone medicine.disease Body Height Adult height Idiopathic short stature Growth hormone treatment Treatment Outcome Body Composition Quality of Life business Psychosocial medicine.drug |
| Zdroj: | Growth Hormone & IGF Research. 18:111-135 |
| ISSN: | 1096-6374 |
| DOI: | 10.1016/j.ghir.2007.11.003 |
| Popis: | In the management of ISS auxological, biochemical, psychosocial and ethical elements have to be considered. In boys with constitutional delay of growth and puberty androgens are effective in increasing height and sexual characteristics, but adult height is unchanged. GH therapy is efficacious in increasing height velocity and adult height, but the inter-individual variation is considerable. The effect on psychosocial status is uncertain. Factors affecting final height gain include GH dose, height deficit in comparison to midparental height, age and first year height velocity. In case of a low predicted adult height at the onset of puberty, addition of a GnRH analogue can be considered. Although GH therapy appears safe, long-term monitoring is recommended. |
| Databáze: | OpenAIRE |
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