Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors
| Autor: | Anna Stallmann, Karen Cherkis, Saijun Tang, Jeffery L. Dangl, Vera Bonardi, Melinda Roberts |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Proceedings of the National Academy of Sciences. 108:16463-16468 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1113726108 |
| Popis: | Plants and animals deploy intracellular immune receptors that perceive specific pathogen effector proteins and microbial products delivered into the host cell. We demonstrate that the ADR1 family of Arabidopsis nucleotide-binding leucine-rich repeat (NB-LRR) receptors regulates accumulation of the defense hormone salicylic acid during three different types of immune response: ( i ) ADRs are required as “helper NB-LRRs” to transduce signals downstream of specific NB-LRR receptor activation during effector-triggered immunity; ( ii ) ADRs are required for basal defense against virulent pathogens; and ( iii ) ADRs regulate microbial-associated molecular pattern-dependent salicylic acid accumulation induced by infection with a disarmed pathogen. Remarkably, these functions do not require an intact P-loop motif for at least one ADR1 family member. Our results suggest that some NB-LRR proteins can serve additional functions beyond canonical, P-loop–dependent activation by specific virulence effectors, extending analogies between intracellular innate immune receptor function from plants and animals. |
| Databáze: | OpenAIRE |
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