Aeroallergen sensitization correlates with PC20 and exhaled nitric oxide in subjects with mild-to-moderate asthma
| Autor: | Stephen I. Wasserman, Timothy J. Craig, Ronald R. Zimmerman, Nikolina Icitovic, Tonya S. King, Michael E. Wechsler, Robert F. Lemanske |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Allergy Adolescent Immunology Provocation test Nitric Oxide medicine.disease_cause Immunoglobulin E Allergic sensitization Hypersensitivity Prevalence Humans Immunology and Allergy Medicine Child Sensitization Aged Skin Tests Asthma Air Pollutants biology business.industry Aeroallergen Allergens Middle Aged medicine.disease Respiratory Function Tests respiratory tract diseases medicine.anatomical_structure Exhaled nitric oxide biology.protein Female business |
| Zdroj: | Journal of Allergy and Clinical Immunology. 121:671-677 |
| ISSN: | 0091-6749 |
| Popis: | Background Aeroallergen sensitization in adult asthmatic patients from a wide geographic area has not been correlated with patients' characteristics, markers of airways inflammation, and lung function. Objective We assessed data obtained from the Asthma Clinical Research Network trials to determine the relationship of aeroallergen sensitization to age, sex, ethnicity, and markers of inflammation and airways function. Methods Skin testing (14 epicutaneous) was performed on 1338 subjects with objectively diagnosed mild-to-moderate asthma from 11 Asthma Clinical Research Network studies. Skin testing used identical techniques and a quality assurance program to ensure uniformity across centers. Results Ninety-five percent of the subjects had at least 1 positive skin test response. Of these, 14% had positive reactions to 1 or 2 allergens and 81% had positive reactions to 3 or more allergens, and 2% of subjects reacted only to seasonal allergens, 26% only to perennial allergens, and 67% to both. Increasing IgE and exhaled nitric oxide values, decreasing PC 20 values, and minority ethnicity significantly correlated with the number of positive skin test responses. Subjects with late-onset asthma were less likely to be sensitized; nonetheless, 89% of subjects older than 60 years had positive responses. Conclusion Ninety-five percent of patients with mild-to-moderate asthma might have an allergic component. Age does not significantly affect aeroallergen sensitization, but the pattern of allergic sensitization varies with ethnicity and geography. Measures used to characterize asthma, such as IgE, exhaled nitric oxide, and PC 20 values, are correlated with aeroallergen sensitization. |
| Databáze: | OpenAIRE |
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