Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza
| Autor: | Timothy H. Rainer, Rita Y. K. Wong, Kin-Wing Choi, David S.C. Hui, Wai-Yip Lam, Clive S. Cockram, Ida M.T. Chu, Eric Wong, Nelson Lee, Raymond Lai, Bonnie C. K. Wong, Paul K.S. Chan, Joseph J.Y. Sung, Grace Lui |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Aging medicine.medical_specialty Oseltamivir Time Factors medicine.disease_cause Antiviral Agents Gastroenterology Major Articles Major Articles and Brief Reports chemistry.chemical_compound Internal medicine Influenza Human medicine Influenza A virus Humans Immunology and Allergy Prospective Studies Viral shedding Aged Asthma business.industry Influenza A Virus H3N2 Subtype Odds ratio Middle Aged Viral Load medicine.disease Virus Shedding Hospitalization Infectious Diseases Viral replication chemistry Viruses Immunology Viral disease business Viral load |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/600383 |
| Popis: | BackgroundThe goal of this study was to characterize viral loads and factors affecting viral clearance in persons with severe influenza MethodsThis was a 1-year prospective, observational study involving consecutive adults hospitalized with influenza. Nasal and throat swabs were collected at presentation, then daily until 1 week after symptom onset. Real-time reverse-transcriptase polymerase chain reaction to determine viral RNA concentration and virus isolation were performed. Viral RNA concentration was analyzed using multiple linear or logistic regressions or mixed-effect models ResultsOne hundred forty-seven inpatients with influenza A (H3N2) infection were studied (mean age ± standard deviation, 72±16 years). Viral RNA concentration at presentation positively correlated with symptom scores and was significantly higher than that among time-matched outpatients (control subjects). Patients with major comorbidities had high viral RNA concentration even when presenting >2 days after symptom onset (mean ± standard deviation, 5.06±1.85 vs 3.62±2.13 log10 copies/mL; P=.005; β, +0.86 [95% confidence interval, +0.03 to +1.68]). Viral RNA concentration demonstrated a nonlinear decrease with time; 26% of oseltamivir-treated and 57% of untreated patients had RNA detected at 1 week after symptom onset. Oseltamivir started on or before symptom day 4 was independently associated with an accelerated decrease in viral RNA concentration (mean β [standard error], −1.19 [0.43] and −0.68 [0.33] log10 copies/mL for patients treated on day 1 and days 2–3, respectively; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|