Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors
| Autor: | Claire Briet, Frédéric Illouz, Patrice Rodien, Doreen Braun, Ulrich Schweizer |
|---|---|
| Přispěvatelé: | Biologie Neurovasculaire et Mitochondriale Intégrée (BNMI), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Rheinische Friedrich-Wilhelms-Universität Bonn, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Univ Angers, Okina, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Angers (UA) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Thyroid Hormones endocrine system endocrine system diseases Thyroid Gland/drug effects/metabolism Endocrinology Diabetes and Metabolism [SDV]Life Sciences [q-bio] Thyroid Function Tests/methods Thyroid Gland 030209 endocrinology & metabolism Antineoplastic Agents Endocrine System Thyroid Function Tests Protein Kinase Inhibitors/adverse effects Thyroid function tests 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Endocrine system Animals Endocrine System/drug effects/metabolism Humans Protein Kinase Inhibitors Thyroid Diseases/chemically induced/metabolism medicine.diagnostic_test Sunitinib business.industry Thyroid General Medicine Antineoplastic Agents/adverse effects Thyroid Diseases 3. Good health respiratory tract diseases [SDV] Life Sciences [q-bio] medicine.anatomical_structure 030220 oncology & carcinogenesis Anti cancer drugs Thyroid Hormones/metabolism business Tyrosine kinase medicine.drug Thyroid effects |
| Zdroj: | European Journal of Endocrinology European Journal of Endocrinology, 2014, 171 (3), pp.R91-9. ⟨10.1530/EJE-14-0198⟩ |
| ISSN: | 0804-4643 1479-683X |
| DOI: | 10.1530/EJE-14-0198⟩ |
| Popis: | International audience; Tyrosine kinase inhibitors (TKIs) are currently used by most oncologists. Among their side effects, thyroid dysfunctions are nowadays clearly observed. Whereas changes in thyroid function tests have been originally described with sunitinib, we now know that many TKIs can induce hypothyroidism and hyperthyroidism. In this study, the various molecules implicated in thyroid dysfunctions are analysed and the latest data on physiopathological mechanisms are approached in order to propose a strategy of thyroid monitoring of patients on TKI therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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