Anatomic and Cellular Niches for Mycobacterium tuberculosis in Latent Tuberculosis Infection
| Autor: | Stephen T. Reece, Adrian R. Martineau, Irene Andia, Mulugeta Belay, Jonathan Mayito, David A. Jolliffe, David P. Kateete |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
bone marrow Tuberculosis media_common.quotation_subject Library science Review Article Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Latent Tuberculosis Excellence Political science medicine mesencymal stem cells Humans Immunology and Allergy 030212 general & internal medicine media_common Phagocytes Government biology Latent tuberculosis Mesenchymal Stem Cells Hematopoietic Stem Cells biology.organism_classification medicine.disease 3. Good health 030104 developmental biology Infectious Diseases Alliance CD34 |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Latent tuberculosis has been recognized for over a century, but discovery of new niches, where Mycobacterium tuberculosis resides, continues. We evaluated literature on M.tuberculosis locations during latency, highlighting that mesenchymal and hematopoietic stem cells harbor organisms in sensitized asymptomatic individuals. Studies suggest that mesenchymal and hematopoietic stem cells may be niches for M tuberculosis during latent infection. We propose that propagation of infection by these cells may contribute to anatomical and cellular distribution of M tuberculosis in latently infected individuals. |
| Databáze: | OpenAIRE |
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