Utility of Digital Stereo Images for Optic Disc Evaluation
| Autor: | Judith Alexander, William Nyberg, Manika Puri, Maureen G. Maguire, Denise J. Pearson, Eydie Miller, Jayan Eledath, Jody R. Piltz-Seymour, Mayank Bansal, Harpreet Sawhney, Gui-Shuang Ying, Richard A. Stone |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Computer science Optic Disk ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION Nerve fiber layer Optic disk Ocular hypertension Glaucoma Digital image Ophthalmology Optic Nerve Diseases Image Processing Computer-Assisted Photography medicine Humans Computer vision Intraocular Pressure ComputingMethodologies_COMPUTERGRAPHICS Aged Aged 80 and over Observer Variation business.industry Reproducibility of Results Articles Middle Aged medicine.disease eye diseases medicine.anatomical_structure Optic nerve Female Ocular Hypertension sense organs Artificial intelligence business Optic disc |
| Zdroj: | Investigative Opthalmology & Visual Science. 51:5667 |
| ISSN: | 1552-5783 |
| DOI: | 10.1167/iovs.09-4999 |
| Popis: | Glaucoma diagnosis, management, and research require complex assessments of the optic disc. Over many decades, the gold standard of optic disc evaluation in glaucoma has been the qualitative evaluation of stereo photographic images of the optic disc, most typically as 35-mm slides or other film-based media. More recently, automated optic disc analyzers have been introduced that use either laser technologies or polarized light to image the optic disc and/or the retinal nerve fiber layer. Studies with these instruments infrequently compare them directly to stereo photographs, and available reports generally find their diagnostic precision comparable to stereo photographs.1–5 So far, the qualitative evaluation of stereo optic disc images by experienced observers remains the reference standard for optic disc evaluation in glaucoma6–8 despite the subjectivity and variability inherent in this conventional approach.9,10 As examples, contemporary clinical glaucoma trials, such as the Ocular Hypertension Treatment Study (OHTS),11,12 the Low-Pressure Glaucoma Treatment Study (LoGTS)13 and the European Glaucoma Prevention Study (EGPS),14,15 used human observers to grade conventional stereo photos to evaluate the optic disc. We are adapting modern computer vision methods to optic disc diagnosis in glaucoma but were concerned with the limited number of published comparisons of digital and film imaging formats for optic disc photographs, as ophthalmic photography has migrated from film-based to digital images. The few published reports mostly have assessed the utility of digital optic nerve images for quantitative parameters long used in glaucoma evaluation, such as the cup-to-disc ratio.16–21 In contrast, in a considerably more extensive body of literature, the utility of digital images has been compared to that of film images in retinal diseases such as diabetic retinopathy22–26 or macular degeneration.27–29 To address the suitability of digital stereo optic disc images as a platform for developing novel computerized approaches for glaucoma diagnosis, we assessed the quality and definition of optic disc features by directly comparing optic disc images obtained from individual subjects and displayed in different formats. We sought to avoid the well-known inaccuracies in trying to assign quantitative estimates such as the cup-to-disc ratio.9,10 Specifically, we obtained stereo color optic disc images contemporaneously in both digital and 35-mm slide film formats in subjects with a range of optic disc cup sizes and included both scanned and grayscale images in the analysis. |
| Databáze: | OpenAIRE |
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