N-Aminosulfamide peptide mimic synthesis by alkylation of aza-sulfurylglycinyl peptides
| Autor: | Stéphane Turcotte, Samir H. Bouayad-Gervais, William D. Lubell |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Sulfonyl Models Molecular Aza Compounds Alkylation Molecular Structure Sulfur Compounds Peptidomimetic Stereochemistry Organic Chemistry Peptide Tripeptide Biochemistry Photo-reactive amino acid analog Amides Amino acid chemistry Nitrogen atom Biomimetic Materials Organic chemistry Physical and Theoretical Chemistry Peptides Amination |
| Zdroj: | Organic letters. 14(5) |
| ISSN: | 1523-7052 |
| Popis: | N-Aminosulfamides are peptidomimetics in which the C(α)H and the carbonyl of an amino acid residue are both respectively replaced by a nitrogen atom and a sulfonyl group. Aza-sulfurylglycinyl tripeptide analogs were effectively synthesized from amino acid building blocks by condensations of N-protected amino hydrazides and p-nitrophenylsulfamidate esters. The installation of N-alkyl chains and access to other aza-sulfuryl amino acid residues were effectively achieved by chemoselective alkylation. |
| Databáze: | OpenAIRE |
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