Calcium signaling and cell proliferation
| Autor: | Henning Ulrich, Mauro Cunha Xavier Pinto, Rodrigo R. Resende, Fernanda Maria Policarpo Tonelli, Vânia Aparecida Mendes Goulart, Alexandre Hiroaki Kihara, Katia N. Gomes |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_element
Calcium Endoplasmic Reticulum Cell membrane medicine Animals Humans Calcium Signaling Calcium signaling Cell Proliferation Cell Nucleus Voltage-dependent calcium channel Cell growth ORAI1 Chemistry Endoplasmic reticulum Cell Membrane Membrane Proteins Cell Biology Cell biology Mitochondria medicine.anatomical_structure Membrane protein BIOQUÍMICA Calcium Channels |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1873-3913 |
| Popis: | Cell proliferation is orchestrated through diverse proteins related to calcium (Ca(2+)) signaling inside the cell. Cellular Ca(2+) influx that occurs first by various mechanisms at the plasma membrane, is then followed by absorption of Ca(2+) ions by mitochondria and endoplasmic reticulum, and, finally, there is a connection of calcium stores to the nucleus. Experimental evidence indicates that the fluctuation of Ca(2+) from the endoplasmic reticulum provides a pivotal and physiological role for cell proliferation. Ca(2+) depletion in the endoplasmatic reticulum triggers Ca(2+) influx across the plasma membrane in an phenomenon called store-operated calcium entries (SOCEs). SOCE is activated through a complex interplay between a Ca(2+) sensor, denominated STIM, localized in the endoplasmic reticulum and a Ca(2+) channel at the cell membrane, denominated Orai. The interplay between STIM and Orai proteins with cell membrane receptors and their role in cell proliferation is discussed in this review. |
| Databáze: | OpenAIRE |
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