Treatment of dehiscence‐type defects with collagen matrix and/or enamel matrix derivative: Histomorphometric study in minipigs
| Autor: | Isabela Lima França-Grohmann, Márcio Zaffalon Casati, Renato Corrêa Viana Casarin, Karina Gonzales Silvério Ruiz, Enilson Antonio Sallum, João Paulo Menck Sangiorgio, Manuela Rocha Bueno, Francisco Humberto Nociti |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Swine Connective tissue Dehiscence Matrix (biology) 03 medical and health sciences 0302 clinical medicine Dental Enamel Proteins Enamel matrix derivative medicine Animals Gingival Recession Cementum Gingival recession Gingivoplasty business.industry Chemistry Soft tissue 030206 dentistry Treatment Outcome 030104 developmental biology medicine.anatomical_structure Connective Tissue Swine Miniature Periodontics Collagen medicine.symptom Nuclear medicine business Gingival margin |
| Zdroj: | Journal of Periodontology. 91:967-974 |
| ISSN: | 1943-3670 0022-3492 |
| Popis: | BACKGROUND This study aimed to evaluate, histomorphometrically, the use of collagen matrix (CM) and/or enamel matrix derivative (EMD) for the treatment of dehiscence-type recession defects in minipigs. METHODS Eight healthy, male, young BR-1 minipigs, with no periodontal disease were treated. Bilateral dehiscence-type defects were surgically created on the buccal of the mandibular premolars (PI and PII). After 30 days, the defects were randomly assigned to four groups: coronally advanced flap (CAF); CAF + CM; CAF + EMD; and CAF + CM + EMD (split-mouth design). The evaluated parameters (mm): total defect length; new cementum (NC); new bone (NB); gingival margin position; total epithelium length; epithelium on the root; connective tissue adaptation; and soft tissue thickness (STT). RESULTS The EMD-treated groups showed a superior length of NC [4.13 ± 1.22 (CAF + EMD); 3.95 ± 1.11 (CAF + CM + EMD); 2.94 ± 0.77 (CAF + CM); 2.72 ± 0.81 (CAF), P = 0.02] and NB [3.21 ± 0.68 (CAF + CM + EMD); 3.01 ± 0.56 (CAF + EMD); 2.15 ± 0.47 (CAF + CM); 2.29 ± 0.82 (CAF), P = 0.005]. The CAF and CAF + CM groups showed a superior epithelial length when compared to EMD-treated groups after 3 months. A superior STT was observed for CAF + CM + EMD group (1.5 ± 0.33) when compared with the other groups [1.09 ± 0.26 (CAF + EMD); 1.04 ± 0.34 (CAF + CM); and 1.14 ± 0.29 (CAF), P = 0.03]. CONCLUSION(S) The results of the present study indicate that EMD application, irrespective of the combination with CM, may improve the periodontal regeneration of dehiscence-type defects in this animal model. |
| Databáze: | OpenAIRE |
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