Fifty Shades of α-Ketoglutarate on Cellular Programming
| Autor: | Ping-Chih Ho, Chin-Hsien Tsai, Giusy Di Conza |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Brain Neoplasms Cell NF-kappa B Cell Biology Biology Cell biology 03 medical and health sciences Glucose deprivation Glucose 0302 clinical medicine medicine.anatomical_structure Glutamate dehydrogenase 1 Cancer cell medicine biology.protein Humans Ketoglutaric Acids Glycolysis Metabolic Stress Cellular programming Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Molecular Cell. 76:1-3 |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/j.molcel.2019.09.002 |
| Popis: | High plasticity to utilize different nutrients to adapt metabolic stress is one of the hallmarks for cancer cells. However, the underlying mechanisms by which cancer cells reprogram metabolic machinery in response to metabolic stress remain largely unclear. In this issue of Molecular Cell, Wang et al. (2019) report that glutamate dehydrogenase 1 (GDH1) induces an unconventional regulation of the NF-κB pathway under glucose deprivation, thereby stimulating glycolysis in glioblastomas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|