Does androgen influence prolactin secretion?
| Autor: | J. M. Nolin, D. D. Nansel, E. M. Bogdanove, G. T. Campbell |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Ventral prostate endocrine system medicine.medical_specialty medicine.drug_class Biology urologic and male genital diseases Sex Factors Estrus Pregnancy Internal medicine medicine Animals Testosterone Secretion Castration Drug Implants Estradiol Prostate Dihydrotestosterone General Medicine Luteinizing Hormone Androgen Prolactin Rats Endocrinology Female hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Endocrine Research Communications. 4:61-70 |
| ISSN: | 0093-6391 |
| DOI: | 10.1080/07435807709045734 |
| Popis: | In both intact and castrated male and female rats, administration of the A-ring reduced androgen, dihydrotestosterone (DHT), consistently failed to stimulate prolactin (PRL) secretion although it inhibited LH release and, in males, stimulated ventral prostate growth. In intact females, but not in the other types of rat, DHT actually suppressed PRL release. These findings do not support generalizations, based entirely on findings with testosterone, that both "androgens" and estrogens exert stimulatory actions on PRL secretion. The distinct stimulatory effects of testosterone and its esters on PRL secretion seem attributable, not to their androgenic actions per se, but to the ability of testosterone to form estrogenic metabolites. This ability does not appear to be shared by the "pure" androgen, DHT. |
| Databáze: | OpenAIRE |
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