Stimulation of drug-metabolizing enzymes by nitrous oxide in the rat
| Autor: | E. Pieraccioli, Piero Dolara, V.A. Peduto, Gian Paolo Novelli, Ludovici M, Emanuela Masini |
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| Rok vydání: | 1983 |
| Předmět: |
Male
Pentobarbital Time Factors Urinary system Nitrous Oxide Stimulation Pharmacology chemistry.chemical_compound medicine Animals Enzyme inducer Benzopyrene Hydroxylase chemistry.chemical_classification biology Dose-Response Relationship Drug business.industry Oxidoreductases N-Demethylating Rats Inbred Strains General Medicine Nitrous oxide gamma-Glutamyltransferase Stimulation Chemical Rats Oxygen Drug metabolizing enzymes Anesthesiology and Pain Medicine Enzyme chemistry Liver Enzyme Induction biology.protein Aryl Hydrocarbon Hydroxylases Xenobiotic business medicine.drug |
| Zdroj: | Acta anaesthesiologica Scandinavica. 27(6) |
| ISSN: | 0001-5172 |
| Popis: | Wistar male rats were subchronically (150 h continuously) or chronically (5 h daily for 15 days) exposed to a 50% nitrous oxide/oxygen mixture. As an index of enzyme induction liver N-demethylase and benzo(a)pyrene-hydroxylase activities, serum gamma-glutamyltranspeptidase activity, urinary d-glucaric acid and pentobarbital sleeping time were evaluated in comparison with a control group. No effect was observed after subchronic exposure to the anaesthetic gas. Chronic exposure, on the contrary, decreased pentobarbital sleeping time, increased urinary d-glucaric acid, liver N-demethylase and serum gamma-glutamyltranspeptidase activities. No increase of liver benzo(a)pyrene-hydroxylase was observed. Chronic nitrous oxide exposure under appropriate conditions can modify some enzymes, metabolizing drugs and xenobiotic compounds. |
| Databáze: | OpenAIRE |
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